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Autores: Alex Krummenauer, Hugo Marcelo Veit, Marcelo Pilotto Cenci, Luis Henrique Lapazin

Resumo:Using a portable energy dispersive X-ray fluorescence (EDXRF) spectrometer and certified reference materials, the linearity, the limit of detection (LOD), the limit of quantification (LOQ), and the working range of the method were determined for the quantitative analysis of base and precious metals in liquid matrices. As the EDXRF method is not standardized and strongly sensitive to matrix effects, these calculations are essential to its analytical validation. In this study, the resulting R2 values were higher than 0.99 and the residuals had random distribution. The LOD and LOQ values were considered low, close to the resolution of the spectrometer. Thus, our calculations confirmed the analytical validation of the portable EDXRF method in liquid matrices. The utilization of portable EDXRF equipment in the quantitative measurement of elements in liquid matrices is innovative and reveals new fields of application for this type of instrument.

Autores: Mariana Cardoso de Oliveira, Vanderléa de Souza, Marcelo Dominguez de Almeida

Resumo:Nitrate and nitrite measurement is a fundamental part of quality control in the meat products industries. Ensuring the technical validity of the results of these measurements can be achieved through the adoption of appropriate metrological tools such as method validation. In this study, the measurement of the mass fractions of nitrite and nitrate ions was performed by ion chromatography with UV detection. The method was linear (r > 0.99) over the working range. Limits of quantification values for measuring nitrite and nitrate in meat product were 10 mg kg-1 and 100 mg kg-1 , respectively. The mean values of recovery at all evaluated mass fraction levels were within the range of 88 % to 106 %. All the validation parameters resulted as satisfactory and the method was considered adequate for the intended use.

Autores: Vinicius do Nascimento Moraes, Jessyca Gomes da Silva, Alexia Santana Barradas

Resumo:A Cabine de segurança biológica é um equipamento que deve ser projetado para fornecer proteção ao pessoal, ao ambiente e a amostra manipulada. O consistente desempenho das cabines ocorre quando os procedimentos apropriados de garantia da conformidade a requisitos especificados e manutenção são seguidos. Neste trabalho foram discutidos aspectos relacionados à avaliação metrológica das cabines de segurança biológica classe II. Sendo o problema principal a ser apresentado a falta de harmonização em aspectos como: testes realizados para avaliação da conformidade, a terminologia descritiva dos serviços e falta de uma diretriz nacional específica que padronize a avaliação metrológica do item. Foram avaliados equipamentos nacionais e importados, de sete fabricantes, em dez diferentes usuários, localizados em quatro estados do Brasil. Dos equipamentos avaliados, 45% apresentaram alguma falha na fabricação que comprometem o operador eou a amostra. E 50% apresentaram algum parâmetro em não conformidade com os parâmetros de desempenho especificados pela norma SFA/ANSI 49.

Autores: Gabriel Cataldo de Morais, Ruan C Mayworm, Danielle Tallia Giosa, Flávia Noemy Gasparini Kiatake Fontão, José Mauro Granjeiro, Rodrigo P.B. Costa-Felix

Resumo: Dentistry implants methods are recursively enhancing the image localisation approach to improve patient point of intercession accuracy. Previous planning of the surgical act is on the cut edge of the technology. Materials that mimic the implant house, i.e., the maxillary bone, have been developed and improved material technology. Standard non-invasive and non-ionising radiation technologies are relevant tools to that approach. Ultrasound imaging techniques play a prominent role in that matter. Nevertheless, recent polymer materials specially developed to help the pre-implant studies had not been evaluated about their homogeneity of ultrasound parameters. Two specially developed polymer materials have their speed of sound analysed in a metrologically based methodology. At 1 MHz, a set of 10 blocks were considered statistically equivalent, unless one specimen. The speed of sound was 1020 m s -1 (expanded uncertainty for p = 0.95 equals 22 m s -1 ) and 1676 m s -1 (U0.95 = 10 m s -1 ). The ultrasound homogeneity is a vital outcome of the reliability of those materials used in dentistry implant pre-clinical studies.

Autores: Edilvando Pereira Eufrázio, Fábio Silva de Oliveira, Leonardo de Farias Linhares

Resumo:Os ensaios de resistência ao rasgo, em implantes mamários, são executados de forma a obter parâmetros estatísticos, visto que a normativa base não determina valores para os testes. Objetivo: Verificar se há diferença estatística na força de rasgo entre os diferentes materiais de fabricação e ainda entre fabricantes distintos. Metodologia: As amostras consistem nos corpos de prova de três fabricantes de implantes e três tipos de membranas. Resultados: Fez-se uma avaliação estatística não paramétrica entre o valor mediano da força máxima de rasgo. Conclusão: Há diferenças em relação às resistências ao rasgo entre as diferentes marcas.

Autores: Vinícius Tostes Seixas, Carlos Roberto Hall Barbosa, Elisabeth Costa Monteiro

Resumo:Noninvasive magnetic mapping for locating non-ferromagnetic metallic foreign bodies, such as firearm projectiles, has a promising application for guiding accurate surgical removals. The strategy consists of inducing eddy currents in the metallic object by applying an external alternating magnetic field. A secondary magnetic field generated by the induced currents in the foreign body can be detected by a high-sensitivity transducer. Previously proposed systems presented constraints to the measurement capability of the transducer imposed by the primary magnetic field interference on their sensing elements. Overcoming these limitations, this work proposes a new configuration of the system that decouples the excitation and measuring stages, arranging their elements symmetrically to generate a spatial distribution of the field lines in such a way that adequate magnetic flux density levels are produced in the region of the foreign body, with values nearly not-detectable at the sensor location. Thereby, the secondary field generated by the induced eddy currents can be amplified, allowing the detection of smaller fragments located at greater depth distances from the skin. The measuring system concept, the spatial distribution of the primary and secondary magnetic fields, and the new approach’s performance to localize foreign bodies are presented.

Autores: Marcos Rogozinski, Carlos Roberto Hall Barbosa, Elisabeth Costa Monteiro

Resumo:Ferromagnetic foreign bodies accidentally inserted in patients usually need to be surgically removed. Their location can be estimated by measuring the magnetic field generated by the object and solving the magnetic inverse problem to locate the source based on the magnetic field maps configuration. Considering ferromagnetic straight needles (hypodermic or sewing, for example) and a computer simulation of the magnetic flux density based on BiotSavart’s Law, this paper presents an algorithm based on Convolutional Neural Networks (CNN) to find the depth, the angles of inclination and rotation and the center of the needle inside the human body. The proposed model presents low RMSE values and type A measurement uncertainty for the depth, the inclination angle, the rotation angle, and for the displacement Δ between the midpoint of the distance connecting the magnetic field extreme values and the foreign body center, all of which adequate for use in therapeutic procedures.

Autores: Handressa Pereira Fêu Laviola, Aurea Valadares Folgueras Flatschart, José Mauro Granjeiro

Resumo:The biotechnology sector is constantly growing; this is evident when we observe the sector’s demand for financial investments and international cooperation. In parallel, the need for professionals to work within a quality management system adequately is also growing. Brazilian bachelor’s in biology and Biotechnology are allowed by the Federal Council of Biology (FCB) as biotechnologists without specialization. In this work, we aimed to evaluate the training of undergraduate students of Biotechnology and Biology courses in topics related to Quality Management. A survey was carried out on the curricula content of several higher education institutions, available online. From this information, we identified that more than half of the courses do not provide information and training capable of preparing the student to work, even in a primary way, under Quality Management Systems. We emphasize the need for a reformulation in these curricula to guarantee adequate training of its students to the market.

Autores: Luciana e Sá Alves, José Mauro Granjeiro

Resumo:O objetivo do artigo é apresentar as diretrizes estratégicas para o ensino de metrologia no Brasil estabelecidas desde o ano de 2003 e provocar uma reflexão sobre a importância com que o tema é tratado nos documentos de referência e sobre as ações implementadas a partir destas diretrizes. Essa reflexão é fundamental neste momento, tendo em vista que as novas diretrizes estratégicas serão discutidas e publicadas no ano que vem, cobrindo o período entre os anos de 2023 a 2027. O Congresso Brasileiro de Metrologia é o fórum privilegiado para tal discussão no país. A metodologia utilizada foi o levantamento bibliográfico. A reflexão feita após o estudo das quatro edições já publicadas do documento Diretrizes Estratégicas para a Metrologia Brasileira mostrou que há 18 anos o mesmo texto é utilizado para constituir o capítulo dedicado ao ensino de metrologia.

Autores: Alessandra Faria-Campos, Handressa Pereira-Fêu, João Vinícius Nóia, Aurea Folgueras-Flatschart, José Mauro Granjeiro, Sérgio Campos

Resumo:Good Laboratory Practices – GLP, are a set of principles that define a quality system. They have been designed to ensure that laboratory experimentation is performed appropriately. Quality management systems in general and GLP compliant ones in particular are becoming more important every day. GLP compliance facilitates the acceptance of data in the context of regulatory processes where authorities have to assess the safety of new products. As a consequence, it is an important tool to overcome technical export barriers to OECD member countries. However, compliance to these systems can be complex. As a consequence, many laboratories are unable to implement GLPs in their daily activities risking to lose competitiveness in the market. In this work we present BPL++, a Laboratory Information Management System that assists in implementing GLP compliance in laboratories. BPL++ is an efficient and easy to use system with a Web based interface. It can simplify GLP adoption and increase laboratory competitiveness. BPL++ has been evaluated by GLP experts and is currently being used at INMETRO.